Everyone knows the ubiquitous Deadpool by now. He's everywhere. He's in every comic.
Deadpool is a spoof on actual superheroes. What makes him work is he points out the ridiculousness of superheroes and the comic book medium in general.
So what do you call a spoof of a spoof? Dead-Pooh. That's right - Winnie the Pooh reimagined as Deadpool.
So this leads me to think... what other mashups can we come up with? Here are my initial offerings:
Bugs Bunny + Batman = Batbunny
+ 
Popeye + Hulk = Hulkeye
+ 
Smurfs + Marvel Mutants = X-Smurfs
... Hmm... I guess that last one really wasn't so different after all.